- A blood transfusion is a safe procedure in which blood, or parts of blood, is given to through an intravenous (IV) line. Nearly 5 million Americans of all ages receive blood transfusions each year.
- Many people who have surgery need blood transfusions because they lose blood during their operations. People who have serious injuries also may need blood transfusions to replace lost blood. Some people need blood transfusions because they have illnesses that prevent their bodies from properly making blood or parts of blood.
- Blood may be transfused as "whole blood" containing all blood components or as individual parts. The individual parts that may be transfused include red blood cells (RBCs), platelets, clotting factors, and plasma.
- A person's blood type is determined before they receive a blood transfusion. This is necessary so that he or she receives blood that matches his or her own blood.
- When there isn't time to test for blood type (such as during an emergency), type O blood is used. Type O is safe for almost everyone.
- Blood transfusions usually take 1 to 4 hours and can be provided in a doctor's office (outpatient) or in the hospital. The time depends on how much blood you need and what part of the blood you receive.
- Most blood transfusions go smoothly. However, mild problems and, very rarely, serious problems can occur. They include allergic reactions, transmission of viruses and infectious diseases, fever, iron overload, lung injury, reactions from receiving the wrong blood type, and immune system problems.
- There is currently no synthetic alternative to human blood. However, there are medications, such as erythropoietin, that can reduce a person's need for blood transfusions
- Surgeons try to reduce the amount of blood lost during surgery so that fewer patients need blood transfusions. Sometimes they can collect and reuse the blood for the patient.
Every person has one of the following blood types: A, B, AB, or O. Also, every person's blood is either Rh-positive (Rh+) or Rh-negative (Rh-). So, if you have type A blood, it's either A positive or A negative.
The blood used in a transfusion must match the recipient's blood type. If it doesn't, antibodies in the recipient's blood attack the new blood and makes the person sick.
Type O blood is safe for almost everyone. About 40% of the population has type O blood. People who have this blood type are called universal donors. Type O blood is used for emergencies when there's no time to test a person's blood type.
People who have type AB blood are called universal recipients. This means they can get any type of blood.
If you have Rh-positive blood, you can get Rh-positive or Rh-negative blood. But if you have Rh-negative blood, you should only get Rh-negative blood. Rh-negative blood is used for emergencies when there's no time to test a person's Rh type.
Blood banks collect, test, and store blood. They carefully screen all donated blood for possible infectious agents, such as viruses, that could make you sick.
To prepare blood for a transfusion, some blood banks remove white blood cells. This process is called white cell or leukocyte reduction. Although rare, some people are allergic to white blood cells in donated blood. Removing these cells makes allergic reactions less likely.
Not all transfusions use blood donated from a stranger. If you're going to have surgery, you may need a blood transfusion because of blood loss during the operation. If it's surgery that you're able to schedule months in advance, your doctor may ask whether you would like to use your own blood, rather than donated blood.
If you choose to use your own blood, you will need to have blood drawn one or more times prior to the surgery. A blood bank will store your blood for your use.
Types of Blood Transfusions
Blood is transfused either as whole blood (with all its parts) or, more often, as individual parts. The type of blood transfusion you need depends on your situation. For example, if you have an illness that stops your body from properly making a part of your blood, you may need only that part to treat the illness.
Red Blood Cell (RBC) Transfusions
Red blood cells are the most commonly transfused part of the blood. These cells carry oxygen from the lungs to your body's organs and tissues. They also help your body get rid of carbon dioxide and other waste products.
You may need a transfusion of red blood cells if you've lost blood due to an injury or surgery. You also may need this type of transfusion if you have severe anemia due to disease or blood loss.
Anemia is a condition in which your blood has a lower than normal number of red blood cells. Anemia also can occur if your red blood cells don't have enough hemoglobin.
Hemoglobin is an iron-rich protein that gives blood its red color. This protein carries oxygen from the lungs to the rest of the body.
Platelets and Clotting Factor Transfusions
Platelets and clotting factors help stop bleeding, including internal bleeding that you can't see. Some illnesses may cause your body to not make enough platelets or clotting factors. You may need regular transfusions of these parts of your blood to stay healthy.
For example, if you have hemophilia, you may need a special clotting factor to replace the clotting factor you're lacking. Hemophilia is a rare, inherited bleeding disorder in which your blood doesn't clot normally.
If you have hemophilia, you may bleed for a longer time than others after an injury or accident. You also may bleed internally, especially in the joints (knees, ankles, and elbows).
Plasma is the liquid part of your blood. It's mainly water, but also contains proteins, clotting factors, hormones, vitamins, cholesterol, sugar, sodium, potassium, calcium, and more.
If you have been badly burned or have liver failure or a severe infection, you may need a plasma transfusion.
Reasons To Get a Blood Transfusion
Blood transfusions are very common.
Many people who have surgery need blood transfusions because they lose blood during their operations. For example, about one-third of all heart surgery patients have a transfusion. Some people who have serious injuries, such as from car crashes, war, or natural disasters, need blood transfusions to replace blood lost during the injury.
Some people need blood or parts of blood because of illnesses. You may need a blood transfusion if you have:
- A severe infection or liver disease that stops your body from properly making blood or some parts of blood.
- An illness that causes anemia, such as kidney disease or cancer. Medicines or radiation used to treat a medical condition also can cause anemia. There are many types of anemia, including aplastic, Fanconi, hemolytic, iron-deficiency, and sickle cell anemias and thalassemia.
- A bleeding disorder, such as hemophilia or thrombocytopenia.
Risks of Blood Transfusions
Most blood transfusions go very smoothly. However, mild problems and, very rarely, serious problems can occur.
Some people have allergic reactions to the blood given during transfusions. This can happen even when the blood given is the right blood type.
Allergic reactions can be mild or severe. Symptoms can include:
- Chest and/or back pain
- Trouble breathing
- Fever, chills, flushing, and clammy skin
- A quick pulse or low blood pressure
- Nausea (feeling sick to the stomach)
A nurse or doctor will stop the transfusion at the first signs of an allergic reaction. The health care team determines how mild or severe the reaction is, what treatments are needed, and whether the transfusion can safely be restarted.
Viruses and Infectious Diseases
Some infectious agents, such as HIV, can survive in blood and infect the person receiving the blood transfusion. To keep blood safe, blood banks carefully screen donated blood.
The risk of catching a virus from a blood transfusion is very low.
- HIV. Your risk of getting HIV from a blood transfusion is lower than your risk of getting killed by lightning. Only about 1 in 2 million donations might carry HIV and transmit HIV if given to a patient.
- Hepatitis B and C. The risk of having a donation that carries hepatitis B is about 1 in 205,000. The risk for hepatitis C is 1 in 2 million. If you receive blood during a transfusion that contains hepatitis, you'll likely develop the virus.
- Variant Creutzfeldt-Jakob disease (vCJD). This disease is the human version of Mad Cow Disease. It's a very rare, yet fatal brain disorder. There is a possible risk of getting vCJD from a blood transfusion, although the risk is very low. Because of this, people who may have been exposed to vCJD aren't eligible blood donors.
You may get a sudden fever during or within a day of your blood transfusion. This is usually your body's normal response to white blood cells in the donated blood. Over-the-counter fever medicine usually will treat the fever.
Some blood banks remove white blood cells from whole blood or different parts of the blood. This makes it less likely that you will have a reaction after the transfusion.
Getting many blood transfusions can cause too much iron to build up in your blood (iron overload). People who have a blood disorder like thalassemia, which requires multiple transfusions, are at risk for iron overload. Iron overload can damage your liver, heart, and other parts of your body.
If you have iron overload, you may need iron chelation therapy. For this therapy, medicine is given through an injection or as a pill to remove the extra iron from your body.
Although it's unlikely, blood transfusions can damage your lungs, making it hard to breathe. This usually occurs within about 6 hours of the procedure. Most patients recover. However, 5-25% of patients who develop lung injuries die from the injuries. These people usually were very ill before the transfusion.
Doctors aren't completely sure why blood transfusions damage the lungs. Antibodies (proteins) that are more likely to be found in the plasma of women who have been pregnant may disrupt the normal way that lung cells work. Because of this risk, hospitals are starting to use men's and women's plasma differently.
Acute Immune Hemolytic Reaction
Acute immune hemolytic reaction is very serious, but also very rare. It occurs if the blood type you get during a transfusion doesn't match or work with your blood type. Your body attacks the new red blood cells, which then produce substances that harm your kidneys.
The symptoms include chills, fever, nausea, pain in the chest or back, and dark urine. The doctor will stop the transfusion at the first sign of this reaction.
Delayed Hemolytic Reaction
This is a much slower version of acute immune hemolytic reaction. Your body destroys red blood cells so slowly that the problem can go unnoticed until your red blood cell level is very low.
Both acute and delayed hemolytic reactions are most common in patients who have had a previous transfusion.
Graft-versus-host disease (GVHD) is a condition in which white blood cells in the new blood attack your tissues. GVHD usually is fatal. People who have weakened immune systems are the most likely to get GVHD.
Symptoms start within a month of the blood transfusion. They include fever, rash, and diarrhea. To protect against GVHD, people who have weakened immune systems should receive blood that has been treated so the white blood cells can't cause GVHD.