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Endometriosis-Related Pain

Researchers know that pain is a primary symptom of endometriosis, but it is not known how pain arises in women with endometriosis.

The severity of pain does not correspond with the number, location, or extent of endometriosis lesions. Some women with only a few small lesions experience severe pain; other women may have very large patches of endometriosis, but only experience little pain.3,4

Current evidence suggests several possible explanations for pain associated with endometriosis, including (but not limited to)3,4:

Pain from endometriosis can be severe, interfering with day-to-day activities. Understanding how endometriosis is related to pain is a very active area of research because it could allow for more effective treatments for this specific type of pain.

Reference: National Institute of Child Health and Human Development


Last updated April 20, 2017

1 American College of Obstetricians and Gynecologists. (2008). Endometriosis. Washington, DC.

2 Tietjen, G. E., Bushnell, C. D., Herial, N. A., Utley, C., White, L., & Hafeez, F. (2007). Endometriosis is associated with prevalence of comorbid conditions in migraine. Headache, 47(7), 1069-1078.

3 American College of Obstetricians and Gynecologists. (2008). Endometriosis. Washington, DC.

4 Stratton, P., & Berkley, K.J. (2011). Chronic pelvic pain and endometriosis: Translational evidence of the relationship and implications. Human Reproduction Update, 17(3), 327-346.