Kalamazoo Nerve Center, PLLC

Parkinson's Disease

Amantadine for Parkinson's Disease

What is Amantadine?

Amantadine is a prescription medication used to reduce the symptoms of Parkinson’s disease, conditions similar to Parkinson’s disease, and the side effects of other Parkinson’s disease medications.

Amantadine may also be used for the treatment of influenza and MS-related fatigue.

How does Amantadine work?

Many of the symptoms of Parkinson’s disease are caused by a deficiency of a neurotransmitter in the brain called dopamine.

Amantadine is thought to help nerve endings release dopamine and make it more available to dopamine receptors. When used without other Parkinson’s disease treatments, it is most effective during early stages of the disease.

Many people with Parkinson’s disease take levodopa, a medication to increase dopamine levels in the brain. After long-term use of levodopa, many patients develop dyskinesia, a movement disorder characterized by jerky, uncontrolled movements. Although the it is not fully understood why these dyskinesias develop, amantadine has been shown to reduce the levodopa-induced dyskinesia.

What are the side effects of Amantadine?

The most common side effects of amantadine include nausea, dizziness, and insomnia. Other side effects may include mottled skin, edema, agitation, or hallucinations.

Take amantadine exactly as directed by your doctor. Do not take more or less of it or take it more often than prescribed by your doctor.


Reference: National Library of Medicine