Fibrates (fibric acid derivatives)

Fibrates are a category of medication prescribed to lower the risk of developing heart disease.

Fibrates are usually prescribed to patients whose triglyceride level is high (hypertriglyceridemia). They are also prescribed in combination with statins for those whose whose "good cholesterol" (HDL) level is low, or for those who do not tolerate statins.

Although less effective in lowering "bad cholesterol' (LDL) than statins, fibrates improve HDL and triglyceride levels. They mays also improve insulin resistance in those with metabolic syndrome (hypertension and diabetes mellitus type 2).

Fibrates currently available in the U.S. include:

  • Gemfibrozil (Lopid®)
  • Fenofibrate (Antara®, Lofibra®, Tricor®, and Triglide®)
  • Clofibrate (Atromid-S)

Side effects of Fibrates

Commonly reported side effects include mild stomach upset and muscle pain. The use of fibrates also increases the risk for developing gallstones.

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Last updated: 5/13/2022