Otezla® (Apremilast)

Otezla® treats psoriasis and psoriatic arthritis by regulating inflammation within the cell.

It inhibits an enzyme known as phosphodiesterase 4 (PDE4). This enzyme controls much of the inflammatory action within cells, which can affect the level of inflammation associated with psoriatic disease.

How is Otezla® used?

Otezla® is available as a 30-milligram (mg) tablet. The first five days is a start period, where the dosage will gradually increase until the recommended dose of 30 milligrams twice daily is reached.

Otezla® is meant to be taken continuously to maintain improvement.

What are the risks?

There have been rare reports of:

  • Gastrointestinal problems, including diarrhea, nausea and vomiting
  • Depression
  • Weight decrease

Common side effects

In clinical trials, the most common side effects were diarrhea, nausea, headache and upper respiratory infection.

Using Otezla® with other treatments

Otezla® can be used with other treatments such as phototherapy or topicals. It has been shown to be safe and effective when taken with methotrexate. Talk to your health care provider about whether using any other treatments with Otezla® is right for you.

Last updated May 18, 2018

Reference: National Psoriasis Foundation

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