The age of biologics has made a tremendous impact on the care of psoriasis. These medicines have opened up a new world of safe and effective treatments for our worst psoriasis sufferers. They are often my first choice for "whole body" and/or lifestyle affecting psoriasis, where topical therapies just can't do the job or aren't practical.
Stelara® is a nice addition to our current treatment options. It offers a novel mechanism of action, so patients that have perhaps failed other biologics in the past, have hope with this drug. It also offers less frequent dosing than our other options, essentially every 12 weeks after the initial induction phase.
Our primary concern with Stelara® right now is the lack of long term safety data, relative to the other biologic and non-biologic therapies. Safety, before efficacy, needs to be our first goal.
Currently, I am comfortable with Stelara® as a 2nd line biologic agent for patients that have failed one of my first options, or as a first line option if their medical history suggests Stelara® would be safer.
Plaque psoriasis is the most common form of psoriasis. Plaque psoriasis is diagnosed in 80% of people with psoriasis.
The plaques appear as red, raised, inflamed lesions covered with a silvery white layer of flakey scales. They may vary in size from a 1/2 inch to 6 inches in diameter. Plaques may grow together, creating large affected areas.
Plaques (as those shown in the images) occur most commonly on the scalp, knees, elbows, and lower back, but they can appear anywhere on the body, including the genitals.
Fingernails and toenails may also be affected, causing pitted, whitened, and thickened nails.
Plaque psoriasis also has these characteristics:
In general, mild psoriasis can usually be treated effectively with a variety of psoriasis treatments.
Topical medications are usually recommended as a first-line treatment for mild cases where there is limited area to be treated. Commonly prescribed topical medications include the following:
Localized plaques on the hands or feet may not respond to topical medications and may be treated with laser light.
Moderate to severe psoriasis may require use of systemic treatments, such oral medications (methotrexate, cyclosporine), or biologics (Enbrel®, Humira®, Remicade®, Stelara®).
Phototherapy may also be recommended for widespread plaque psoriasis.
Many psoriasis medications may be used in combination. For instance, topical corticosteroids may be used in combination with vitamin D derivatives. Biologics may be used in combination with methotrexate or phototherapy.
Your doctor will prescribe a treatment plan based on several variables including the following:
Image courtesy of the National Psoriasis Foundation.